Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs

T Inoue; K Kikuchi; K Hirose; M Iino; T Nagano

doi:10.1016/s0960-894x(99)00256-5

Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1697-702. doi: 10.1016/s0960-894x(99)00256-5.

Authors

T Inoue¹, K Kikuchi, K Hirose, M Iino, T Nagano

Affiliation

¹ Graduate School of Pharmaceutical Science, The University of Tokyo, Department of Pharmacology, Japan.

PMID: 10397504
DOI: 10.1016/s0960-894x(99)00256-5

Abstract

IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding, Competitive
Calcium Channels / metabolism
Cloning, Molecular
Humans
Inositol 1,4,5-Trisphosphate / analogs & derivatives*
Inositol 1,4,5-Trisphosphate / chemical synthesis
Inositol 1,4,5-Trisphosphate / metabolism
Inositol 1,4,5-Trisphosphate Receptors
Molecular Structure
Receptors, Cytoplasmic and Nuclear / metabolism
Surface Plasmon Resonance

Substances

Calcium Channels
ITPR1 protein, human
Inositol 1,4,5-Trisphosphate Receptors
Receptors, Cytoplasmic and Nuclear
Inositol 1,4,5-Trisphosphate